Important Things to Keep in Mind:

There are many tips and tricks that you can use to improve your profitability with Adsense, but it is never a good idea to get too far away from the basics either.
For that reason, we have included here some of the more general aspects of using Adsense in order to maximizing its overall effectiveness.
When your content changes, so do your ads.
The technology behind Google AdSense goes beyond simple keyword or category matching. In essence, they try to understand your content and deliver ads that are relevant to specific pages, automatically, no matter how many thousands of pages your site may have, or how specialized or broad your content. With that being the case, as your content changes, Google's ads change to match.
What that means to you is that if you go changing your content too much; do not be surprised if the ads change as well.
And while many people complain about Google, they do offer some very useful safeguards which you may want to explore.
• Competitive ad filters. You can block competitive ads, or other ads you want to keep off your site, simply by telling them which URLs to block.
• Ad Review. Before ads appear on your site, they're reviewed using a combination of human and automated processes. The review process takes into account a variety of factors, including the quality of the ad and whether it's suitable for all audiences.
• Sensitive content filters. At times, certain ads may be inappropriate for some pages. For example, Google automatically filters out ads that would be inappropriate on a news page about a catastrophic event.
• Choose your own default ads. In the unlikely event that Google is unable to serve targeted ads on your page, they offer you the option of displaying a default ad of your choice. This ensures that your advertising space is always being used as effectively as possible.
Customize ads to complement your site.
Google offers you a lot of choices when it comes to design. While it is better to stick with the more traditional look, you can, if you wish to experiment or test, choose something else. They offer over 200 colors and 24 pre-set color palettes—you can create and save your own custom palettes using a simple point-and-click color selection tool.
One thing you simply must do is track your earnings with online reports.
You can monitor your ad performance with customizable online reports that offer details like the number of page impressions, clicks and click-through rate.
You can track the performance of specific ad formats, colors, and pages, which can help you, identify trends quickly. These reporting tools let you group your pages however you want, so you can gain insight into your earnings by viewing results by URL, domain, ad type, category and more.

Track your results online.

You can track the number of queries, clicks, click-through-rate—as well as your Adsense earnings—via a web-based account which you can easily update at any time.
As we said, this may not be for everyone, but for many marketers, this is a good option to look into. It offers a lot of perks.
We hope this guide has been useful to you. The only way that it will really be useful, however, is if you use the information contained within.
Now, please understand that some of the techniques that we have included in this guide may be too aggressive for you. Using them may make you nervous. If that is the case, you should avoid using them or try to modify them in such a way that you can sleep at night. There is nothing worse than being nervous over a business matter or a matter of conscious.
It is your job to maximize your site and to make it profitable, but do that within your own comfort zone.
We wish you all the best of luck!